. Molecular changes of preclinical scrapie can be detected by infrared spectroscopy. J Neurosci. 2002 Apr 15;22(8):2989-97. PubMed.


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  1. Q & A with Gabrielle Strobel, ARF, and Dieter Nauman, Robert Koch Institute, Berlin.

    Q: Could this technique be developed to detect early pathological changes in Alzheimer Disease? Can it pick up low-molecular weight protein aggregates?

    A: Our diagnostic FT-IR technique can definitely be used also for the analysis of pathological changes in Alzheimer's diseased tissue. A similar FT-IR approach that aimed, however, at the in-situ deposition of Aβ in tissues has been published recently (Choo et al. 1996) FT-IR is already being used to characterize low molecular-weight aggregates.

    Q: Could FT-IR be adapted to be used in live animals?

    A: The FT-IR technique described is on tissues, there is no way to use it for live animals or humans, as e.g. MRI. But we are currently developing a similar TSE diagnostic technology that can be used on blood serum of individuals.  ‑ Gabrielle Strobel


    . In situ characterization of beta-amyloid in Alzheimer's diseased tissue by synchrotron Fourier transform infrared microspectroscopy. Biophys J. 1996 Oct;71(4):1672-9. PubMed.

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