. Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1. Neurobiol Aging. 2008 May;29(5):639-52. PubMed.

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Comments

  1. How is it that PS1(n-/-) mice have on one side severe neurodegeneration (Shen et al., 2007) and here only a subtle impairment in Schaffer LTP?

    References:

    . The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):403-9. PubMed.

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