Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB, Lee VM, Brunden KR. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci. 2012 Mar 14;32(11):3601-11. PubMed.

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News

  1. Paper Alert: Microtubule Stabilizer Improves Tauopathy in Mice
  2. Spastin Leads to Severed Microtubules in Tau-Filled Dendrites
  3. At Least We Know These Don’t Work: Negative Trials at CTAD

Research Models

  1. Tau P301S (Line PS19)

Therapeutics

  1. Epothilone D