- Alzforum Recommends
Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, Martin L, Louis JC, Yan Q, Richards WG, Citron M, Vassar R. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci. 2001 Mar;4(3):231-2. PubMed.
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Institute of Neurology, UCL
"An excellent paper, not only establishing BACE as b -secretase but also suggesting that knockout (or, by implication drug inhibition) may not have major adverse effects."
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