. Maternal history of dementia is associated with amyloid deposition in clinically normal older individuals. Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;


Positive family history of dementia (FH+) is a significant risk factor for clinical Alzheimer’s disease (AD), particularly when there is a maternal history. Recent studies of clinically normal (CN) adult offspring have linked maternal history of AD to reduced gray matter volume and FDG hypometabolism. However, little is known about the relationship of family history to amyloid pathology, particularly in the absence of clinical symptomatology. We tested whether FH+ CN subjects had greater amyloid deposition and whether this was more evident in those with a maternal history.

We evaluated PiB PET data from a total of 58 CN (CDR 0) individuals (mean age 72±8) who stated that they knew the cognitive status of their parents after the age of 63. Of these, 29 (mean age 70±7) reported they were FH+ and 29 (mean age 75±8) were FH-. Within the FH+ group, 21 subjects reported maternal histories of dementia (mFH+), 5 reported paternal histories (pFH+), and 3 reported dementia in both parents. We evaluated our hypothesis in 12 ROIs, covarying age.

Compared to FH-, FH+ subjects had greater cortical PiB retention in widespread frontal lateral, frontal, and parietal ROIs (pSelf-reported parental history of dementia is associated with increased amyloid deposition in clinically normal individuals. The association appears to be driven by maternal history of dementia, and it is observed independently of APOE status. These findings are consistent with the hypothesis that amyloid deposition occurs prior to any clinical symptoms, and that family history is a significant risk factor for the development of AD pathology.


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  1. Toronto: HAI Amyloid Imaging Conference Abstracts