. Low-power laser irradiation inhibiting Abeta25-35-induced PC12 cell apoptosis via PKC activation. Cell Physiol Biochem. 2008;22(1-4):215-22. PubMed.

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  1. Zhang et al. study inhibition of Aβ25-35-induced PC12 cell apoptosis using low-power laser irradiation. This study is based on an assumption that Aβ25-35 is the critical region that mediated neurotoxicity of full-length Aβ. On the other hand, substantial genetic, in vitro, and mouse model evidence demonstrates that there are significant differences between the two dominant alloforms, Aβ40 and Aβ42, both in terms of prefibrillar oligomeric structures and neurotoxicity. It would be important to explore how low-power laser irradiation would affect cell apoptosis induced by these two full-length peptides.

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