. Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1. EMBO J. 2002 Nov 1;21(21):5787-96. PubMed.


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  1. So much that has been important for the understanding of APP biology has come from C elegans (and Drosophila). This paper is probably going to have a long-term importance.

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