Desai P, Evans D, Dhana K, Aggarwal NT, Wilson RS, McAninch E, Rajan KB. Longitudinal Association of Total Tau Concentrations and Physical Activity With Cognitive Decline in a Population Sample. JAMA Netw Open. 2021 Aug 2;4(8):e2120398. PubMed.

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  1. This is a very interesting study on AD biomarkers and physical activity (PA). It is probably one of the first studies to longitudinally evaluate PA in the association between total tau in serum and cognitive function.

    Those persons with high levels of tau had a slower cognitive decline if they had high levels of PA. People with both low and high levels of tau had a slower cognitive decline if they engaged in medium or high levels of PA.

    The results support the possibility of using blood biomarkers in measuring the benefits associated with PA, and eventually other health behaviors, and they may help to specify target populations or to tailor interventions for trials.

    There are some limitations: This is a population-based observational cohort, so the direction of causation is unclear. Also, PA was self-reported and the intensity is not known.

    In future, other plasma AD biomarkers could be analyzed. We aim to study this in the FINGER trial and within WW-FINGERS network that evaluate multi-domain lifestyle interventions.

    View all comments by Miia Kivipelto

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