. Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. Am J Epidemiol. 2005 Aug 15;162(4):305-17. PubMed.


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  1. This is a well-done paper; it emphasizes the need for meta-analyses to decipher relevant from irrelevant results in genetically complex diseases. Readers of this paper may also be interested in the continuously updated meta-analysis on the Alzforum's AD genetic database AlzGene.

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