. Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes. J Biol Chem. 2006 Oct 20;281(42):31279-89. PubMed.


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  1. Finally, a very sound analysis provides a model to explain the strange pharmacology of gamma-secretase modulators and inhibitors.

    It can even incorporate the previous report on partial active site knock-outs.

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