. Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid beta toxicity in Alzheimer's disease. FEBS J. 2009 May;276(10):2736-51. PubMed.


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  1. This is certainly a very exciting paper! Shaker et al. provide a novel and plausible mechanistic association between β amyloid and calcium dysregulation in neurons from AD patients, thereby establishing a link between sporadic AD and calcium signaling alterations. To date, presenilin mutations associated with familial AD have been the dominant model to illustrate the interaction of calcium disruptions with AD pathology. It will be interesting to see follow-up studies in live neurons and mouse models.

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