. Interaction of apolipoprotein E epsilon 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator. Neurochem Res. 1998 Mar;23(3):369-76. PubMed.

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  1. Apolipoprotein E4 allele is established to be the major susceptibility gene for late onset Alzheimer Disease (AD) but still needs more study to clarify its function. This is valuable on the viewpoint of genetic association study.

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