. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. J Biol Chem. 1998 Mar 27;273(13):7185-8. PubMed.


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  1. This study is a new experiment that may be interesting. It might be just a radical scavenger but melatonin is interesting because it crosses BB-barrier.

  2. Regarding the above comment by Dr Mori, the inhibition of beta-sheet structures and amyloid fibrils by melatonin is NOT exclusively dependent on its antioxidant activity but appears to be due to a unique combination of antioxidant AND structural features of the hormone (other antioxidants do not have the same effects).

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