Tsai CL, Liang CS, Yang CP, Lee JT, Ho TH, Su MW, Lin GY, Lin YK, Chu HT, Hsu YW, Yang FC. Indicators of rapid cognitive decline in amnestic mild cognitive impairment: The role of plasma biomarkers using magnetically labeled immunoassays. J Psychiatr Res. 2020 Oct;129:66-72. Epub 2020 Jun 9 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ40
(Plasma)		 AD
(19)		 52.7 ± 3.2
pg/mL		 Immunomagnetic Reduction;
MF-AB0-0060;
MagQu Co. Ltd.		 McKhann et al., 2011
Aβ40
(Plasma)		 CTRL-
CNC
(10)		 53 ± 4.8
pg/mL		 Immunomagnetic Reduction;
MF-AB0-0060;
MagQu Co. Ltd.
Aβ42
(Plasma)		 AD
(19)		 17.4 ± 0.9
pg/mL		 Immunomagnetic Reduction;
MF-AB2-0060;
MagQu Co. Ltd.		 McKhann et al., 2011
Aβ42
(Plasma)		 CTRL-
CNC
(10)		 16.6 ± 0.7
pg/mL		 Immunomagnetic Reduction;
MF-AB2-0060;
MagQu Co. Ltd.
tau-p181
(Plasma)		 AD
(19)		 3.8 ± 0.7
pg/mL		 Immunomagnetic Reduction;
MF-PT1-0060;
MagQu		 McKhann et al., 2011
tau-p181
(Plasma)		 CTRL-
CNC
(10)		 3.4 ± 0.6
pg/mL		 Immunomagnetic Reduction;
MF-PT1-0060;
MagQu
tau-total
(Plasma)		 AD
(19)		 26.4 ± 4.2
pg/mL		 Immunomagnetic Reduction;
MF-TAU-0060;
MagQu		 McKhann et al., 2011
tau-total
(Plasma)		 CTRL-
CNC
(10)		 23 ± 3.5
pg/mL		 Immunomagnetic Reduction;
MF-TAU-0060;
MagQu
α-synuclein
(Plasma)		 AD
(19)		 145.1 ± 78
fg/mL		 Immunomagnetic Reduction;
MF-ASC-0060;
MagQu Co. Ltd.		 McKhann et al., 2011
α-synuclein
(Plasma)		 CTRL-
CNC
(10)		 115.8 ± 83.9
fg/mL		 Immunomagnetic Reduction;
MF-ASC-0060;
MagQu Co. Ltd.

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This paper appears in the following:

AlzBiomarker

  1. AD vs CTRL : Aβ40 (Plasma and Serum)
  2. CTRL vs AD : Aβ40 (Plasma and Serum)
  3. AD vs CTRL : Aβ42 (Plasma and Serum)
  4. CTRL vs AD : Aβ42 (Plasma and Serum)
  5. AD vs CTRL : tau-p181 (Plasma and Serum)
  6. CTRL vs AD : tau-p181 (Plasma and Serum)
  7. AD vs CTRL : tau-total (Plasma and Serum)
  8. CTRL vs AD : tau-total (Plasma and Serum)
  9. AD vs CTRL : α-synuclein (Plasma and Serum)
  10. CTRL vs AD : α-synuclein (Plasma and Serum)