Wellington H, Paterson RW, Portelius E, Törnqvist U, Magdalinou N, Fox NC, Blennow K, Schott JM, Zetterberg H. Increased CSF neurogranin concentration is specific to Alzheimer disease. Neurology. 2016 Mar 1;86(9):829-35. Epub 2016 Jan 29 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
neurogranin
(CSF)		 AD
(100)		 612 ± 539
ng/L §		 Electrochemiluminescence;
In-house;
In-house
neurogranin
(CSF)		 CTRL-
CNC
(19)		 242 ± 177
ng/L §		 Electrochemiluminescence;
In-house;
In-house
neurogranin
(CSF)		 DLB
(13)		 205 ± 140
ng/L §		 Electrochemiluminescence;
In-house;
In-house		 McKeith et al., 1996
neurogranin
(CSF)		 FTD-
Speech variant
(21)		 280 ± 146
ng/L §		 Electrochemiluminescence;
In-house;
In-house		 1994
neurogranin
(CSF)		 FTD-
bvFTD
(20)		 249 ± 201
ng/L §		 Electrochemiluminescence;
In-house;
In-house		 1994
neurogranin
(CSF)		 MSA
(29)		 212 ± 128
ng/L §		 Electrochemiluminescence;
In-house;
In-house		 Gilman et al., 2008
neurogranin
(CSF)		 PD
(31)		 270 ± 236
ng/L §		 Electrochemiluminescence;
In-house;
In-house		 Hughes et al., 1992
neurogranin
(CSF)		 PSP
(46)		 255 ± 211
ng/L §		 Electrochemiluminescence;
In-house;
In-house		 Litvan et al., 1996

§ Data supplied to Alzforum by author

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