. An immunohistochemical study of centenarian brains: a comparison. J Neurol Sci. 1998 Apr 15;157(1):73-81. PubMed.


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  1. The abstract for this paper states 'the relative mildness of the age-related morphological changes in the cnetenarians compared with the AD patients suppors the idea that AD would not be the ultimate condition of the aging process'. This conclusion is consistent with data of West et al in Lanet which showed AD and control brains differ in their pattern of neuronal loss in subdivisions of hippocampus.

  2. It is important because it suggests a more general disturbance in protein processing in AD. The presence of huntingtin in NFTs is clearly secondary to the AD and suggest that the metabolism of many different proteins, not just APP or tau, is affected in AD.

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