. Immunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS. J Neurosci. 2015 Apr 22;35(16):6381-93. PubMed.


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  1. We agree with Appel's work that recruitment of Tregs to the spinal cord parenchyma is beneficial in ALS. Yet it is important to note that the optimal way to bring more Tregs to the CNS may not be by increasing their levels in the circulation; on the contrary, increasing their levels in the circulation may be counterproductive (Schwartz and Baruch, 2014).


    . The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus. EMBO J. 2014 Jan 7;33(1):7-22. Epub 2013 Dec 19 PubMed.

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