Sloan SA, Darmanis S, Huber N, Khan TA, Birey F, Caneda C, Reimer R, Quake SR, Barres BA, Paşca SP. Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. Neuron. 2017 Aug 16;95(4):779-790.e6. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. This study has addressed a salient issue in human astrocyte biology. It nicely confirms and extends a previous study by the Barres Lab (Zhang et al., 2016), which characterized purified astrocytes from fetal through to adult stages. It chronicles the transcriptional progression, and acquisition of different functional attributes, during astrocytic maturation using a translational and reductionist human iPSC model.

    These findings will serve as a powerful resource for researchers studying astrocyte developmental biology and also issues of cellular autonomy in a range of neurodegenerative disorders.

    References:

    Zhang Y, Sloan SA, Clarke LE, Caneda C, Plaza CA, Blumenthal PD, Vogel H, Steinberg GK, Edwards MS, Li G, Duncan JA 3rd, Cheshier SH, Shuer LM, Chang EF, Grant GA, Gephart MG, Barres BA. Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse. Neuron. 2016 Jan 6;89(1):37-53. Epub 2015 Dec 10 PubMed.

    View all comments by Rickie Patani

Make a Comment

To make a comment you must login or register.