Takahashi H, Brasnjevic I, Rutten BP, van der Kolk N, Perl DP, Bouras C, Steinbusch HW, Schmitz C, Hof PR, Dickstein DL. Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease. Brain Struct Funct. 2010 Mar;214(2-3):145-60. PubMed.

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  1. A limitation of mouse models of Alzheimer disease has been the lack of neuronal loss. This report indicates a substantial and remarkable loss of interneurons in a knock-in presenilin-1 mutation mouse model. Typically, interneurons have been resistant to cell death in various mouse models of neurological disease so their vulnerability in this mouse model of AD is particularly intriguing. Importantly, interneuron loss in the dentate gyrus derived from postmortem AD confirms the mouse finding. The reason why these neurons are vulnerable remains unclear but may be related to their expression of calcium-binding proteins.

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