. Heightened emotional contagion in mild cognitive impairment and Alzheimer's disease is associated with temporal lobe degeneration. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9944-9. PubMed.


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  1. People with AD are very affected by their surroundings. They get agitated when they need to be hospitalized, or when going to crowded and unfamiliar places. The new data in this paper provide insight into the biological substrate for these symptoms. The authors show that atrophy of temporal lobe structures may be a basis for the heightened emotionality observed in AD patients.

    The symptoms are consistent with disrupted connectivity of the default-mode network and increased connectivity of the salience network, which are commonly seen in MCI and AD and occur in parallel to cognitive decline. The findings suggest that high "emotional contagion" could help with early diagnosis of AD and may be a useful measure for studies in AD animal models, both for evaluating disease mechanisms and testing new therapeutic agents.

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  1. Does Shrinking Temporal Lobe Make AD Patients Overly Sensitive?