Vogt NM, Romano KA, Darst BF, Engelman CD, Johnson SC, Carlsson CM, Asthana S, Blennow K, Zetterberg H, Bendlin BB, Rey FE. The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease. Alzheimers Res Ther. 2018 Dec 22;10(1):124. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
NFL
(CSF)		 AD
(40)		 1628 ± 935
pg/mL		 ELISA;
NF-light;
UmanDiagnostics AB		 McKhann et al., 2011
NFL
(CSF)		 CTRL-
CNC
(335)		 705 ± 489
pg/mL		 ELISA;
NF-light;
UmanDiagnostics AB
neurogranin
(CSF)		 AD
(40)		 488 ± 244
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house		 McKhann et al., 2011
neurogranin
(CSF)		 CTRL-
CNC
(335)		 328 ± 182
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house
tau-p181
(CSF)		 AD
(40)		 74.7 ± 26.9
pg/mL		 ELISA;
Innotest Phospho-Tau181P;
Fujirebio		 McKhann et al., 2011
tau-p181
(CSF)		 CTRL-
CNC
(335)		 45.1 ± 16.4
pg/mL		 ELISA;
Innotest Phospho-Tau181P;
Fujirebio
tau-total
(CSF)		 AD
(40)		 722 ± 300
pg/mL		 ELISA;
Innotest hTAU-Ag;
Fujirebio		 McKhann et al., 2011
tau-total
(CSF)		 CTRL-
CNC
(335)		 310 ± 141
pg/mL		 ELISA;
Innotest hTAU-Ag;
Fujirebio

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This paper appears in the following:

AlzBiomarker

  1. AD vs CTRL : NFL (CSF)
  2. CTRL vs AD : NFL (CSF)
  3. AD vs CTRL : neurogranin (CSF)
  4. CTRL vs AD : neurogranin (CSF)
  5. AD vs CTRL : tau-p181 (CSF)
  6. CTRL vs AD : tau-p181 (CSF)
  7. AD vs CTRL : tau-total (CSF)
  8. CTRL vs AD : tau-total (CSF)