. Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med. 2008 Oct;14(10):1106-11. Epub 2008 Sep 28 PubMed.


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  1. This seems to be a very interesting and consistent hypothesis opening exciting avenues for drug development. Potentially a breakthrough. Has it been possible to reconcile the data with the reference below?


    . Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42. J Neurochem. 1999 Oct;73(4):1584-9. PubMed.

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