. Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein. J Biol Chem. 2005 Aug 5;280(31):28564-71. PubMed.


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  1. This is a very clever approach for identifying cell lines that are defective in gamma-secretase processing. Also, it's interesting that the screen did not reveal additional members of the gamma-secretase complex, and that both nicastrin mutants inhibited cleavage of both Notch and APP.

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