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Aizenstein HJ, Nebes RD, Saxton JA, Price JC, Mathis CA, Tsopelas ND, Ziolko SK, James JA, Snitz BE, Houck PR, Bi W, Cohen AD, Lopresti BJ, Dekosky ST, Halligan EM, Klunk WE. Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol. 2008 Nov;65(11):1509-17. PubMed.
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This paper corroborates neuropathological findings: amyloid deposition can be found in non-demented patients. Correlation with cognitive deficits comes with intensification of amyloidosis and, most importantly, the extension of tau pathology.
Question: why are Abeta oligomers, protofibrils and amyloid deposits observed in non-demented patients not toxic?
Several hypotheses: neuronal reservoir, compensation, not-detectable MCI, or simply that they are not toxic in the human brain, but toxic in the experimental models constructed to demonstrate a toxicity.
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