. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiol Dis. 2000 Dec;7(6 Pt B):673-81. PubMed.


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  1. Interesting followup study. Still more smoke but where is the gun?

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