Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G.
Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
J Biol Chem. 1999 May 14;274(20):13818-23.
PubMed.
This is an interesting paper as it offers a mechanism for the cleavage and association of an important protein. This mechanism may be disturbed by the FAD mutations.
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Mount Sinai School of Medicine, NYU
This is an interesting paper as it offers a mechanism for the cleavage and association of an important protein. This mechanism may be disturbed by the FAD mutations.
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