Bruun M, Rhodius-Meester HF, Koikkalainen J, Baroni M, Gjerum L, Lemstra AW, Barkhof F, Remes AM, Urhemaa T, Tolonen A, Rueckert D, van Gils M, Frederiksen KS, Waldemar G, Scheltens P, Mecocci P, Soininen H, Lötjönen J, Hasselbalch SG, van der Flier WM. Evaluating combinations of diagnostic tests to discriminate different dementia types. Alzheimers Dement (Amst). 2018;10:509-518. Epub 2018 Aug 17 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(275)		 530 ± 167
pg/mL §		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 2011
Aβ42
(CSF)		 DLB
(55)		 741 ± 264
pg/mL §		 ELISA;
Innotest;
Fujirebio		 McKeith et al., 2005
Aβ42
(CSF)		 FTD
(79)		 918 ± 252
pg/mL §		 ELISA;
Innotest;
Fujirebio		 Rascovsky et al., 2011; Gorno-Tempini et al., 2011
Aβ42
(CSF)		 VaD
(29)		 727 ± 264
pg/mL §		 ELISA;
Innotest;
Fujirebio		 Román et al., 1993
tau-p181
(CSF)		 AD
(275)		 85 ± 39
pg/mL §		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 2011
tau-p181
(CSF)		 DLB
(55)		 51 ± 28
pg/mL §		 ELISA;
Innotest;
Fujirebio		 McKeith et al., 2005
tau-p181
(CSF)		 FTD
(79)		 44 ± 18
pg/mL §		 ELISA;
Innotest;
Fujirebio		 Rascovsky et al., 2011; Gorno-Tempini et al., 2011
tau-p181
(CSF)		 VaD
(29)		 44 ± 18
pg/mL §		 ELISA;
Innotest;
Fujirebio		 Román et al., 1993
tau-total
(CSF)		 AD
(275)		 690 ± 407
pg/mL §		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 2011
tau-total
(CSF)		 DLB
(55)		 344 ± 222
pg/mL §		 ELISA;
Innotest;
Fujirebio		 McKeith et al., 2005
tau-total
(CSF)		 FTD
(79)		 330 ± 126
pg/mL §		 ELISA;
Innotest;
Fujirebio		 Rascovsky et al., 2011; Gorno-Tempini et al., 2011
tau-total
(CSF)		 VaD
(29)		 314 ± 162
pg/mL §		 ELISA;
Innotest;
Fujirebio		 Román et al., 1993

§ Data supplied to Alzforum by author

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