. Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem. 2002 Apr 5;277(14):12128-36. PubMed.


Please login to recommend the paper.


  1. This paper describes a novel mechanism for regulating Ab production. Many in the field often talk about the role of trafficking in APP processing, but this paper provides a nice example where Ab production is modulated via a trafficking mechanism, rather than by a secretase directed mechanism. This emphasizes the potential importance of other agents that modulate trafficking in APP processing.

Make a Comment

To make a comment you must login or register.