- Alzforum Recommends
Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J, Dickson DW, Petrucelli L, Mitchell JC, Shaw CE, Miller CC. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nat Commun. 2014 Jun 3;5:3996. PubMed.
Please login to recommend the paper.
UT Southwestern Medical Center at Dallas
The finding of a VAPB-PTPIP51 interaction supporting the ER-mitochondria association is interesting and convincing. The effects of TDP-43 overexpression suggest a potential role for TDP-43 in modulating this ER-mitochondrial association and intracellular calcium signaling. However, from results in the paper, the effects of TDP43 appear to be indirect and mediated via GSK-3β. It will be important to determine if impaired ER-mitochondrial association is a major outcome of TDP-43/GSK-3β activation or if it is one of many downstream pathways leading to pathology in TDP-43 ALS. Nevertheless, the potential link between TDP-43 and intracellular calcium signaling is very interesting.
Make a Comment
To make a comment you must login or register.