. Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study. J Nutr Health Aging. 2009 Jun;13(6):550-7. PubMed.


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  1. Probably the most important sentence of the paper is already part of the abstract: "Although there was a similar dose-response relationship observed in the hippocampus volume and ADAS-cog Final model analyses, the overall changes in psychometric scores and hippocampus volume were not significantly correlated." Without this correlation, the relevance of these post-hoc findings is even more questionable and it is unfortunate that his paper is now used for promoting tramiprostate as a medical food product.

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  1. Medical Foods—Food for Thought, But Think Twice