. Distinct Ca2+ thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondria. FASEB J. 2001 Mar;15(3):565-7. PubMed.

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  1. Cytochrome C is a key mediator of apoptosis. Understanding the factors that cause its release is therefore very important. The observation that the mechanism of release differs between neurons and peripheral cells is quite provocative and could explain the vulnerability of neurons to apoptotic stimuli.

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