. Determinants of 4-repeat tau expression. Coordination between enhancing and inhibitory splicing sequences for exon 10 inclusion. J Biol Chem. 2000 Jun 9;275(23):17700-9. PubMed.


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  1. The importance of the control of tau splicing is clearly critical to the understanding of tau biology in tangle diseases. This is a complex and tightly controlled process as this reference illustrates.

  2. This represents a novel look at Tau regulation and sets the stage for regulating the number of repeats in tau (which affects its tendency to aggregate)

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