. Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay. J Neurochem. 1993 Nov;61(5):1828-34. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
tau-total
(CSF)
AD
(27)
10.9 ± 4.9
pg/mL
ELISA;
Other/Not Specified;
In-house
McKhann et al., 1984
tau-total
(CSF)
CTRL-
Other Controls
(51)
0.1 ± 0.5
pg/mL
ELISA;
Other/Not Specified;
In-house

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  1. AD signature found in CSF: tau increased, Aβ42 decreased

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  1. AD vs CTRL : tau-total (CSF)