Sjögren M, Davidsson P, Wallin A, Granérus AK, Grundström E, Askmark H, Vanmechelen E, Blennow K. Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms. Dement Geriatr Cogn Disord. 2002;13(2):112-8. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(19)		 411 ± 99
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 ALS
(11)		 432 ± 119
pg/mL		 ELISA;
Innotest;
Innogenetics		 Brooks, 1994
Aβ42
(CSF)		 CTRL-
CNC
(17)		 853 ± 161
pg/mL		 ELISA;
Innotest;
Innogenetics
Aβ42
(CSF)		 FTD
(14)		 624 ± 223
pg/mL		 ELISA;
Innotest;
Innogenetics		 1994
Aβ42
(CSF)		 PD
(15)		 680 ± 96
pg/mL		 ELISA;
Innotest;
Innogenetics		 Wallin et al., 1999
albumin ratio
(CSF/Blood)		 AD
(19)		 5.8 ± 1.7
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 McKhann et al., 1984
albumin ratio
(CSF/Blood)		 CTRL-
CNC
(17)		 5.2 ± 1.8
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)		 FTD
(14)		 5.8 ± 1.7
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 1994
albumin ratio
(CSF/Blood)		 PD
(15)		 6.7 ± 2.4
mg/L:g/L		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 Wallin et al., 1999
tau-p181
(CSF)		 AD
(19)		 26.06 ± 10.92
pM		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 ALS
(11)		 13.66 ± 6.54
pM		 ELISA;
Innotest;
Innogenetics		 Brooks, 1994
tau-p181
(CSF)		 CTRL-
CNC
(17)		 15.92 ± 5.72
pM		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 FTD
(14)		 9.07 ± 3.96
pM		 ELISA;
Innotest;
Innogenetics		 1994
tau-p181
(CSF)		 PD
(15)		 14.07 ± 3.11
pM		 ELISA;
Innotest;
Innogenetics		 Wallin et al., 1999
tau-total
(CSF)		 AD
(19)		 919 ± 349
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(17)		 342 ± 116
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 FTD
(14)		 421 ± 120
pg/mL		 ELISA;
Innotest;
Innogenetics		 1994
tau-total
(CSF)		 PD
(15)		 306 ± 65
pg/mL		 ELISA;
Innotest;
Innogenetics		 Wallin et al., 1999

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This paper appears in the following:

AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. ALS vs AD : Aβ42 (CSF)
  3. CTRL vs AD : Aβ42 (CSF)
  4. FTD vs AD : Aβ42 (CSF)
  5. PD vs AD : Aβ42 (CSF)
  6. AD vs CTRL : albumin ratio (CSF)
  7. CTRL vs AD : albumin ratio (CSF)
  8. FTD vs AD : albumin ratio (CSF)
  9. PD vs AD : albumin ratio (CSF)
  10. AD vs CTRL : tau-p181 (CSF)
  11. ALS vs AD : tau-p181 (CSF)
  12. CTRL vs AD : tau-p181 (CSF)
  13. FTD vs AD : tau-p181 (CSF)
  14. PD vs AD : tau-p181 (CSF)
  15. AD vs CTRL : tau-total (CSF)
  16. CTRL vs AD : tau-total (CSF)
  17. FTD vs AD : tau-total (CSF)
  18. PD vs AD : tau-total (CSF)