Sjögren M, Rosengren L, Minthon L, Davidsson P, Blennow K, Wallin A. Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD. Neurology. 2000 May 23;54(10):1960-4. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : NFL (CSF)
- CTRL vs AD : NFL (CSF)
- FTD vs AD : NFL (CSF)
- AD vs CTRL : albumin ratio (CSF)
- CTRL vs AD : albumin ratio (CSF)
- FTD vs AD : albumin ratio (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- FTD vs AD : tau-total (CSF)
Curated Study Data
Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
---|---|---|---|---|
NFL (CSF) |
AD- Early onset (21) |
498 ± 236 pg/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
NFL (CSF) |
AD- Late-onset (21) |
1006 ± 727 pg/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
NFL (CSF) |
CTRL- CNC (18) |
241 ± 166 pg/mL |
ELISA; Other/Not Specified; In-house |
|
NFL (CSF) |
CTRL- CNC (18) |
241 ± 166 pg/mL |
ELISA; Other/Not Specified; In-house |
|
NFL (CSF) |
FTD (18) |
1442 ± 1183 pg/mL |
ELISA; Other/Not Specified; In-house |
1994 |
albumin ratio (CSF/Blood) |
AD- Early onset (21) |
6.4 ± 2.7 (CSF mg/L)/(Serum g/L) |
Nephelometry; Other/Not Specified; Other/Not Specified |
McKhann et al., 1984 |
albumin ratio (CSF/Blood) |
AD- Late-onset (21) |
6.6 ± 1.8 (CSF mg/L)/(Serum g/L) |
Nephelometry; Other/Not Specified; Other/Not Specified |
McKhann et al., 1984 |
albumin ratio (CSF/Blood) |
CTRL- CNC (18) |
5.3 ± 2 (CSF mg/L)/(Serum g/L) |
Nephelometry; Other/Not Specified; Other/Not Specified |
|
albumin ratio (CSF/Blood) |
CTRL- CNC (18) |
5.3 ± 2 (CSF mg/L)/(Serum g/L) |
Nephelometry; Other/Not Specified; Other/Not Specified |
|
albumin ratio (CSF/Blood) |
FTD (18) |
5.8 ± 1.9 (CSF mg/L)/(Serum g/L) |
Nephelometry; Other/Not Specified; Other/Not Specified |
1994 |
tau-total (CSF) |
AD- Early onset (21) |
751 ± 394 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
tau-total (CSF) |
AD- Late-onset (21) |
699 ± 319 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
tau-total (CSF) |
CTRL- CNC (18) |
375 ± 176 pg/mL |
ELISA; Innotest; Innogenetics |
|
tau-total (CSF) |
CTRL- CNC (18) |
375 ± 176 pg/mL |
ELISA; Innotest; Innogenetics |
|
tau-total (CSF) |
FTD (18) |
354 ± 140 pg/mL |
ELISA; Innotest; Innogenetics |
1994 |
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