. Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD. Neurology. 2000 May 23;54(10):1960-4. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
NFL
(CSF)
AD-
Early onset
(21)
498 ± 236
pg/mL
ELISA;
Other/Not Specified;
In-house
McKhann et al., 1984
NFL
(CSF)
AD-
Late-onset
(21)
1006 ± 727
pg/mL
ELISA;
Other/Not Specified;
In-house
McKhann et al., 1984
NFL
(CSF)
CTRL-
CNC
(18)
241 ± 166
pg/mL
ELISA;
Other/Not Specified;
In-house
NFL
(CSF)
CTRL-
CNC
(18)
241 ± 166
pg/mL
ELISA;
Other/Not Specified;
In-house
NFL
(CSF)
FTD
(18)
1442 ± 1183
pg/mL
ELISA;
Other/Not Specified;
In-house
1994
albumin ratio
(CSF/Blood)
AD-
Early onset
(21)
6.4 ± 2.7
(CSF mg/L)/(Serum g/L)
Nephelometry;
Other/Not Specified;
Other/Not Specified
McKhann et al., 1984
albumin ratio
(CSF/Blood)
AD-
Late-onset
(21)
6.6 ± 1.8
(CSF mg/L)/(Serum g/L)
Nephelometry;
Other/Not Specified;
Other/Not Specified
McKhann et al., 1984
albumin ratio
(CSF/Blood)
CTRL-
CNC
(18)
5.3 ± 2
(CSF mg/L)/(Serum g/L)
Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)
CTRL-
CNC
(18)
5.3 ± 2
(CSF mg/L)/(Serum g/L)
Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)
FTD
(18)
5.8 ± 1.9
(CSF mg/L)/(Serum g/L)
Nephelometry;
Other/Not Specified;
Other/Not Specified
1994
tau-total
(CSF)
AD-
Early onset
(21)
751 ± 394
pg/mL
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
AD-
Late-onset
(21)
699 ± 319
pg/mL
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
CTRL-
CNC
(18)
375 ± 176
pg/mL
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
CTRL-
CNC
(18)
375 ± 176
pg/mL
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
FTD
(18)
354 ± 140
pg/mL
ELISA;
Innotest;
Innogenetics
1994

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