. Could linear MRI measurements of hippocampus differentiate normal brain aging in elderly persons from Alzheimer disease?. Surg Radiol Anat. 2007 Feb;29(1):77-81. PubMed.


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  1. It is surprising to read a paper with this title in 2006. It was shown in 1992 that the answer to the question posed in the title is “Yes,” if CT is used instead of MRI (Jobst et al., 1992). The latter paper showed that the medial temporal lobe shrinks with age in normal elderly but that in AD the thickness is usually much less than normal at any given age. Hence, such scans can aid in diagnosis and also in following the rate of progression (Jobst et al., 1994).

    The assessment of the medial temporal lobe in AD was pioneered by Bill Jagust (Seab et al., 1988) and by Mony de Leon (de Leon et al., 1989) and its value has been widely accepted ever since. It is immaterial whether CT or MRI is used as a tool.


    . Early marker for Alzheimer's disease: the atrophic hippocampus. Lancet. 1989 Sep 16;2(8664):672-3. PubMed.

    . Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography. Lancet. 1992 Nov 14;340(8829):1179-83. PubMed.

    . Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease. Lancet. 1994 Apr 2;343(8901):829-30. PubMed.

    . Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease. Magn Reson Med. 1988 Oct;8(2):200-8. PubMed.

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