. Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD. Neurobiol Dis. 2016 May;89:1-9. Epub 2016 Jan 27 PubMed.


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  1. Overall, results in the CCS/SOD mice look very promising, and are consistent with other experimental data that support the concept that altering copper levels in the CNS might have some therapeutic benefits in specific conditions. This could also include diseases like Menke’s disease in which there is a major problem in delivery of copper into the CNS.

    View all comments by Colin Masters
  2. I think the data are very interesting. Some key questions going forward include mechanism—how it works and also what populations might make the most sense to try this in first as it moves forward to testing in people.

    View all comments by Merit Cudkowicz

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