. Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis. Neurochem Int. 2007 Jan;50(1):12-38. PubMed.


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  1. The background dataset for this paper can be found at www.polygenicpathways.co.uk.

    The website contains a list of genes implicated in Alzheimer disease. The site is concerned with relationships between the protein products of these genes rather than with association data or polymorphisms. These genetic aspects are all well-detailed in Alzgene.

    These genes have diverse primary roles, but a large number are also directly or indirectly involved in cholesterol and lipoprotein function. It is these aspects that are highlighted. The signaling lattice created by these genes is discussed in the paper.

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