Ben Bouallègue F, Mariano-Goulart D, Payoux P, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer's disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database. Alzheimers Res Ther. 2017 Apr 26;9(1):32. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (124) |
137 ± 38 ng/L |
xMAP; INNO-BIA AlzBio3; Innogenetics |
McKhann et al., 1984; Dubois et al., 2007 |
| Aβ42 (CSF) |
CTRL- CNC (157) |
196 ± 50 ng/L |
xMAP; INNO-BIA AlzBio3; Innogenetics |
|
| tau-p181 (CSF) |
AD (124) |
60 ± 35 ng/L |
xMAP; INNO-BIA AlzBio3; Innogenetics |
McKhann et al., 1984; Dubois et al., 2007 |
| tau-p181 (CSF) |
CTRL- CNC (157) |
33 ± 16 ng/L |
xMAP; INNO-BIA AlzBio3; Innogenetics |
|
| tau-total (CSF) |
AD (124) |
133 ± 65 ng/L |
xMAP; INNO-BIA AlzBio3; Innogenetics |
McKhann et al., 1984; Dubois et al., 2007 |
| tau-total (CSF) |
CTRL- CNC (157) |
67 ± 34 ng/L |
xMAP; INNO-BIA AlzBio3; Innogenetics |
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