Chiu MJ, Yang SY, Horng HE, Yang CC, Chen TF, Chieh JJ, Chen HH, Chen TC, Ho CS, Chang SF, Liu HC, Hong CY, Yang HC. Combined plasma biomarkers for diagnosing mild cognition impairment and Alzheimer's disease. ACS Chem Neurosci. 2013 Dec 18;4(12):1530-6. Epub 2013 Oct 23 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : tau-total (Plasma and Serum)
- AD vs CTRL : Aβ42 (Plasma and Serum)
- AD vs CTRL : Aβ40 (Plasma and Serum)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ1-40 (Plasma) |
AD (30) |
48.91 ± 29.7 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
McKhann et al., 2011 |
| Aβ1-40 (Plasma) |
AD (31) |
38.27 ± 9.15 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
McKhann et al., 2011 |
| Aβ1-40 (Plasma) |
CTRL- CNC (107) |
71.44 ± 30.75 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
|
| Aβ42 (Plasma) |
AD (30) |
28.15 ± 25.64 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
McKhann et al., 2011 |
| Aβ42 (Plasma) |
AD (31) |
18.61 ± 1.55 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
McKhann et al., 2011 |
| Aβ42 (Plasma) |
CTRL- CNC (107) |
15.29 ± 1.6 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
|
| tau-total (Plasma) |
AD (30) |
73.01 ± 139.38 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
McKhann et al., 2011 |
| tau-total (Plasma) |
AD (31) |
53.57 ± 22.87 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
McKhann et al., 2011 |
| tau-total (Plasma) |
CTRL- CNC (107) |
16.16 ± 9.09 pg/mL § |
Immunomagnetic reduction; Other/Not Specified; In-house |
§ Data supplied to Alzforum by author
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