. Cholinergic white matter pathways make a stronger contribution to attention and memory in normal aging than cerebrovascular health and nucleus basalis of Meynert. Neuroimage. 2020 May 1;211:116607. Epub 2020 Feb 6 PubMed.


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  1. The recent findings of Schmitz and colleagues on the loss of cholinergic integrity in the brain are consistent with those of Jan Willem van Dalen from our group. Based on diffusion tensor imaging and tractography in 87 memory clinic patients, van Dalen reported that degradation of the projections from the nucleus basalis of Meynert is associated with specific clinical symptoms as well as a trend for higher mortality.


    . Neuropsychiatric symptoms of cholinergic deficiency occur with degradation of the projections from the nucleus basalis of Meynert. Brain Imaging Behav. 2017 Dec;11(6):1707-1719. PubMed.

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