. Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology. J Alzheimers Dis. 2003 Feb;5(1):39-48. PubMed.


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  1. As a clinician, I would suggest for early intervention with AChE inhibitors in MCI stage to prolong the compensatory process before clinical manifestation of AD.
    I have a question: is there a relationship of increased mio-inositol and cholinergic activity in MCI? If so, could MI be a marker of MCI which will be develop to AD? How do we explain this phenomena? Thank you.
    Martina Nasrun

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