Zhang H, Ng KP, Therriault J, Kang MS, Pascoal TA, Rosa-Neto P, Gauthier S, Alzheimer’s Disease Neuroimaging Initiative. Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease. Transl Neurodegener. 2018;7:23. Epub 2018 Sep 10 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : VLP-1 (CSF)
- CTRL vs AD : VLP-1 (CSF)
- MCI-AD vs MCI-Stable : VLP-1 (CSF)
- AD vs CTRL : YKL-40 (CSF)
- CTRL vs AD : YKL-40 (CSF)
- MCI-AD vs MCI-Stable : YKL-40 (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| VLP-1 (CSF) |
AD (18) |
189.7 ± 16.6† pg/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
| VLP-1 (CSF) |
CTRL- CNC (32) |
133 ± 6.7† pg/mL |
ELISA; Other/Not Specified; In-house |
|
| VLP-1 (CSF) |
MCI-AD (47) |
184.3 ± 9.4† pg/mL |
ELISA; Other/Not Specified; In-house |
|
| VLP-1 (CSF) |
MCI-Stable (24) |
146 ± 10.6† pg/mL |
ELISA; Other/Not Specified; In-house |
|
| YKL-40 (CSF) |
AD (18) |
471.9 ± 39.5† pg/mL |
ELISA; MicroVue; Quidel Corporation |
McKhann et al., 1984 |
| YKL-40 (CSF) |
CTRL- CNC (32) |
397.2 ± 25.7† pg/mL |
ELISA; MicroVue; Quidel Corporation |
|
| YKL-40 (CSF) |
MCI-AD (47) |
400.7 ± 19.4† pg/mL |
ELISA; MicroVue; Quidel Corporation |
|
| YKL-40 (CSF) |
MCI-Stable (24) |
384 ± 28.1† pg/mL |
ELISA; MicroVue; Quidel Corporation |
† Mean ± SEM
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