Bos I, Vos S, Verhey F, Scheltens P, Teunissen C, Engelborghs S, Sleegers K, Frisoni G, Blin O, Richardson JC, Bordet R, Tsolaki M, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Lleó A, Johannsen P, Freund-Levi Y, Frölich L, Vandenberghe R, Westwood S, Dobricic V, Barkhof F, Legido-Quigley C, Bertram L, Lovestone S, Streffer J, Andreasson U, Blennow K, Zetterberg H, Visser PJ. Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum. Alzheimers Dement. 2019 May;15(5):644-654. Epub 2019 Mar 8 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ38
(CSF)		 AD-
Aβ+
(157)		 2139.6 ± 834.8
pg/mL		 Electrochemiluminescence;
V-PLEX Plus Aβ Peptide Panel 1 (6E10);
Meso Scale Discovery		 McKhann et al., 1984
Aβ38
(CSF)		 CTRL-
CNC; Aβ-
(95)		 2245.7 ± 834.3
pg/mL		 Electrochemiluminescence;
V-PLEX Plus Aβ Peptide Panel 1 (6E10);
Meso Scale Discovery
NFL
(CSF)		 AD-
Aβ+
(157)		 1742.2 ± 2893.2
pg/mL		 ELISA;
NF-light;
UmanDiagnostics AB		 McKhann et al., 1984
NFL
(CSF)		 CTRL-
CNC; Aβ-
(95)		 627.4 ± 293.3
pg/mL		 ELISA;
NF-light;
UmanDiagnostics AB
YKL-40
(CSF)		 AD-
Aβ+
(157)		 193.6 ± 68.7
ng/mL		 ELISA;
Human Chitinase 3-like 1 Quantikine;
R&D Systems, Inc.		 McKhann et al., 1984
YKL-40
(CSF)		 CTRL-
CNC; Aβ-
(95)		 127 ± 45.4
ng/mL		 ELISA;
Human Chitinase 3-like 1 Quantikine;
R&D Systems, Inc.
neurogranin
(CSF)		 AD-
Aβ+
(157)		 155.2 ± 121.4
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
neurogranin
(CSF)		 CTRL-
CNC; Aβ-
(95)		 110.8 ± 224
pg/mL		 ELISA;
Other/Not Specified;
In-house
tau-p181
(CSF)		 AD-
Aβ+
(157)		 86.2 ± 41.1
pg/mL §		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC; Aβ-
(95)		 38.7 ± 12.4
pg/mL §		 ELISA;
Innotest;
Fujirebio
tau-total
(CSF)		 AD-
Aβ+
(155)		 708 ± 445
pg/mL §		 ELISA;
Innotest;
Fujirebio		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC; Aβ-
(95)		 197.3 ± 72.5
pg/mL §		 ELISA;
Innotest;
Fujirebio

§ Data supplied to Alzforum by author

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AlzBiomarker

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