Shaw LM, Vanderstichele H, Knapik-Czajka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter W, Lee VM, Trojanowski JQ, Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol. 2009 Apr;65(4):403-13. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(100)		 144 ± 41
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(114)		 206 ± 55
pg/mL		 xMAP;
AlzBio3;
Innogenetics
tau-p181
(CSF)		 AD
(100)		 42 ± 20
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(114)		 25 ± 15
pg/mL		 xMAP;
AlzBio3;
Innogenetics
tau-total
(CSF)		 AD
(100)		 122 ± 58
pg/mL		 xMAP;
AlzBio3;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(114)		 70 ± 30
pg/mL		 xMAP;
AlzBio3;
Innogenetics

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Comments

  1. I wonder whether the segregation power of this assay would be further strengthened if a marker of gliosis (GFAP, Iba1) or neuronal cell lysis (neurofilament) were added to the set.

    View all comments by Florian Muller

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