Verbeek MM, Kremer BP, Rikkert MO, Van Domburg PH, Skehan ME, Greenberg SM. Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy. Ann Neurol. 2009 Aug;66(2):245-9. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ40
(CSF)		 AD
(72)		 3713 ± 1081
pg/mL		 ELISA;
Other/Not Specified;
Immuno-Biological Laboratories		 McKhann et al., 1984
Aβ40
(CSF)		 CAA
(17)		 2912 ± 977
pg/mL		 ELISA;
Other/Not Specified;
Immuno-Biological Laboratories
Aβ40
(CSF)		 CTRL-
Other Controls
(58)		 4003 ± 1185
pg/mL		 ELISA;
Other/Not Specified;
Immuno-Biological Laboratories
Aβ42
(CSF)		 AD
(72)		 433 ± 135
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CAA
(17)		 355 ± 146
pg/mL		 ELISA;
Innotest;
Innogenetics
Aβ42
(CSF)		 CTRL-
Other Controls
(58)		 838 ± 253
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 AD
(72)		 110 ± 51.8
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CAA
(17)		 66.3 ± 30.2
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 CTRL-
Other Controls
(58)		 47.9 ± 14.8
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 AD
(72)		 712 ± 384
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CAA
(17)		 395 ± 292
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 CTRL-
Other Controls
(58)		 215 ± 78.3
pg/mL		 ELISA;
Innotest;
Innogenetics

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AlzBiomarker

  1. AD vs CTRL : Aβ40 (CSF)
  2. CAA vs AD : Aβ40 (CSF)
  3. CTRL vs AD : Aβ40 (CSF)
  4. AD vs CTRL : Aβ42 (CSF)
  5. CAA vs AD : Aβ42 (CSF)
  6. CTRL vs AD : Aβ42 (CSF)
  7. AD vs CTRL : tau-p181 (CSF)
  8. CAA vs AD : tau-p181 (CSF)
  9. CTRL vs AD : tau-p181 (CSF)
  10. AD vs CTRL : tau-total (CSF)
  11. CAA vs AD : tau-total (CSF)
  12. CTRL vs AD : tau-total (CSF)