. CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer's disease-protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion. J Neurochem. 2021 Mar 15; PubMed.

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  1. I believe this to be a very important paper. A CD33 antibody that mimics the D2 phenotype, rather than just functionally eliminating CD33, could be of great value in treating Alzheimer's disease. Promoting healthy non-inflammatory microglia phagocytosis may be of great help.

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