. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome. Mol Med. 1999 Mar;5(3):160-8. PubMed.


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  1. It seems to me that this paper directly contradicts a recent Nature paper by DeStrooper that proteosome inhibitors had no effect on PS1 (g-secrtase) processing.

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