. Building ProteomeTools based on a complete synthetic human proteome. Nat Methods. 2017 Jan 30; PubMed.


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  1. Genome-wide and transcriptome-wide studies have had a tremendous impact on our current thinking about Alzheimer's disease. Proteome-wide studies could in principle have an even greater impact because of the close link between the disease and the phenomenon of protein aggregation. Technical challenges, however, so far have prevented the great potential of LC-MS methods to be fully exploited. The ProteomeTools project is an exciting development that will undoubtedly help future efforts to uncover the molecular origins of Alzheimer's disease at the proteome level.

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