. Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains. Neurosci Res. 2006 Jan;54(1):24-9. PubMed.

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  1. If BACE1 activity is increased, why don't we find more beta stub in the Alzheimer brain, even in not-yet affected brain areas? While we can agree on the hyperactivity of BACE1 in AD, this does not mean that this is a good target.

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